WebbThymidylate synthase inhibitors increased the incorporation and the therapeutic effect of the [ 125 I]I-UdR in primary glioblastoma cells. Auger electron-emitting thymidine analogs should be further investigated and considered when developing novel and hopefully more efficient therapeutic strategies for NSCLC and glioblastomas. Fingerprint WebbLigand-mediated Induction of Thymidylate Synthase Occurs by Enzyme Stabilization IMPLICATIONS FOR AUTOREGULATION OF TRANSLATION* (Received for publication, …
Cancer stem cells are sensitive to Auger electron therapy
Webb28 jan. 2024 · Mechanistically, compared with KPT-330 alone, K+CS suppresses the expression of CRM1, Rad51, and thymidylate synthase proteins, leading to more … Webb23 maj 2002 · We tested directly whether P. abyssi or Helicobacter pylori thyX (GenBank accession numbers g14916853 and g7464006, respectively) can functionally … cmake empty cache
Papain Exerts an Anti-atherosclerosis Effect with Suppressed …
Webb1 nov. 2001 · Abstract. Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair and which is an important … Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP … Visa mer The following reaction is catalyzed by thymidylate synthase: 5,10-methylenetetrahydrofolate + dUMP $${\displaystyle \rightleftharpoons }$$ dihydrofolate + dTMP By means of reductive Visa mer The use of TS inhibitors has become a main focus of using TS as a drug target. The most widely used inhibitor is 5-fluorouracil (5 … Visa mer In the proposed mechanism, TS forms a covalent bond to the substrate dUMP through a 1,4-addition involving a cysteine nucleophile. The … Visa mer • Carreras CW, Santi DV (1995). "The Catalytic Mechanism and Structure of Thymidylate Synthase". Annual Review of Biochemistry. 64 (1): … Visa mer Thymidylate synthase (TS) plays a crucial role in the early stages of DNA biosynthesis. DNA damage or deletion occur on a daily basis as a result of both endogenous and … Visa mer Click on genes, proteins and metabolites below to link to respective articles. Visa mer • Pyrimidine analogues • Thymidylate synthase inhibitor • Thymidine kinase • Thymidine kinase in clinical chemistry Visa mer Webb15 maj 2004 · Induction of thymidylate synthase expression inhibited Fas induction in response to RTX and Alimta, but not in response to 5-FU. Furthermore, thymidylate … cmake empty cuda_architectures not allowed