Human cyp11a1
Web31 mei 2010 · PubMed Abstract: In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR), adrenodoxin (Adx), and a cytochrome P450 (P450scc or CYP11A1). This complex not only plays a key role in steroidogenesis, but also has long … Web8 okt. 2015 · The analyses of extracted samples using LC/qTOF-MS demonstrate that endogenous 7DHC (Fig. 1A–C) is present in human serum, human epidermis and the pig adrenal gland, as is the product of CYP11A1 ...
Human cyp11a1
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WebCYP11A1 (D8F4F) Rabbit mAb recognizes endogenous levels of total CYP11A1 protein. Species Reactivity: Human, Mouse, Rat. Source / Purification. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CYP11A1 protein. WebCYP11A1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas …
WebPrestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution. Synonym (s): Anti-CYPXIA1, Anti-Cholesterol desmolase, Anti-Cholesterol side-chain cleavage enzyme, Anti-Cytochrome P450 11A1, mitochondrial precursor, Anti-P450 (scc) Human Protein Atlas Number: HPA016436. Web5 okt. 2015 · CYP19A1 has the largest number of conserved residues while CYP11A1 sequences are less conserved. Structural analyses of human CYP11A1, CYP17A1 and CYP19A1 show that critical substrate binding site residues are …
Web27 jun. 2007 · The CYP11A1 gene encodes the cholesterol side-chain cleavage enzyme, also termed cytochrome P450scc, which catalyzes the conversion of cholesterol to pregnenolone in the first step of steroid biosynthesis in mitochondria. WebCYP11A1 Antibodies. Antibodies that detect CYP11A1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target CYP11A1 in Human, Rat and Mouse samples. Our CYP11A1 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse.
In each steroidogenic cell, the expression of the P450scc system proteins is regulated by the trophic hormonal system specific for the cell type. In adrenal cortex cells from zona fasciculata, the expression of the mRNAs encoding all three P450scc proteins is induced by corticotropin (ACTH). The trophic hormones increase CYP11A1 gene expression through transcription factors such as steroidogenic factor 1 (SF-1), by the α isoform of activating protein 2 (AP-2) in the human, and m…
Web5 feb. 2024 · CYP11A1 gene is located on human chromosome 15 (Chung et al., 1986). Its mutations in human patients cause adrenal and gonadal failure (Kim et al., 2008). Similar to the human disease, in mice depletion of Cyp11a1 leads to perinatal death due to deficiency in steroid production (Hu et al., 2002). botach government salesWebTesticular GnRH is involved in the regulation of human spermatogenesis and steroidogenesis. Transcripts of testicular gonadotropin-releasing hormone, ... GnRH-R, cytochrome P450 side-chain cleavage (CYP11A1), and 3beta-hydroxy-steroid dehydrogenase type 2 enzyme (HSD3B2) as well as the ITT levels were significantly … botach helmetWeb29 apr. 2013 · Cyp11a1 or P450scc is a mitochondrial side-chain cleavage enzyme required for the conversion of cholesterol to pregnenolone. It catalyzes the initial and rate-limiting step in the synthesis of steroid … hawkwoods furniture and cabinetryWeb2 feb. 2016 · The mitochondrial P450 11A1 (CYP11A1, EC 1.14.1.9), is a membrane-bound protein localized in the inner mitochondrial membrane of steroidogenic tissues such as the adrenal glands, gonads, and the gut [ 3 ], and commits the first and rate-limiting step of steroidogenesis, the side-chain cleavage of cholesterol to yield pregnenolone. hawkwood stablesWebFig. 2. Immunohistochemistry of paraffin-embedded human placenta using CYP11A1 antibody at dilution of 1:150 (40x lens). Fig. 3. Immunofluorescence analysis of HeLa cells using CYP11A1 antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. hawkwood road car park bournemouthWeb31 mei 2010 · Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol. PDB DOI: 10.2210/pdb3NA0/pdb; Classification: Oxidoreductase, … bota chelsea zatzWebRecombinant Human CYP11A1 protein is a Wheat germ Full length protein 1 to 521 aa range and validated in WB, ELISA, SDS-PAGE. Recombinant Human CYP11A1 protein … bota chelsea tratorada